| 货号 | 17922-5mg |
| 描述 | Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal.1,2,3 3-(4-Pyridyl)indole is a ROCK-I inhibitor (IC50 = 25 µM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay.4 It also inhibits ROCK-II and PRK2, another Rho-dependent kinase, with similar potency, while inhibiting MSK-1 and PKA with relatively weaker potency.4 |
| 别名 | Rho Kinase Inhibitor III;ROCK Inhibitor III;Rockout; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Olson, M.F. Applications for ROCK kinase inhibition. Current Opinion in Cell Biology 20, 242-248 (2008). 2.Narumiya, S.,Tanji, M. and Ishizaki, T. Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion. Cancer Metastasis Reviews 28, 65-76 (2009). 3.Watanabe, K.,Ueno, M.,Kamiya, D., et al. A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nature Biotechnology 25(6), 681-686 (2007). 4.Yarrow, J.C.,Totsukawa, G.,Charras, G.T., et al. Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor. Chemistry & Biology 12(3), 385-395 (2005). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 194.2 |
| 分子式 | C13H10N2 |
| CAS号 | 7272-84-6 |
| 稳定性 | ≥ 2 years |
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