| 货号 | 17868-50mg |
| 描述 | Tilorone is an orally active, antiviral compound that induces interferon production and is reported to have antitumor, anti-inflammatory, and neuroprotective actions.1,2,3 With chronic administration, tilorone induces lysosomal glycosaminoglycan storage, rendering glycosaminoglycans resistant to enzymatic degradation.4 |
| 别名 | NSC 143969; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Stringfellow, D.A. and Glasgow, L.A. Tilorone hydrochloride: An oral interferon-inducing agent. Antimicrobial Agents and Chemotherapy 2(2), 73-78 (1972). 2.Wissing, M.D.,Dadon, T.,Kim, E., et al. Small-molecule screening of PC3 prostate cancer cells identifies tilorone dihydrochloride to selectively inhibit cell growth based on cyclin-dependent kinase 5 expression. Oncology Reports 32, 419-424 (2014). 3.Ratan, R.R.,Siddiq, A.,Aminova, L., et al. Small molecule activation of adaptive gene expression: Tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury. Annals of the New York Academy of Sciences 1147, 383-394 (2011). 4.Fischer, J. Tilorone-induced lysosomal storage of glycosaminoglycans in cultured corneal fibroblasts: Biochemical and physicochemical investigations. Biochemistry Journal 312, 215-222 (1995). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 483.5 |
| 分子式 | C25H34N2O3 • 2HCl |
| CAS号 | 27591-69-1 |
| 稳定性 | ≥ 2 years |
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