3MB-PP1
货号：
17860-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 17860-1mg |
| 描述 | In several model organisms, the generation of conditional analog-sensitive kinase alleles has been developed as a chemical genetic strategy wherein a mutational enlargement of the ATP-binding site enables a protein kinase to interact with bulky ATP analogs.1,2 Thus, a generic bulky ATP analog can competitively inhibit the activity of the mutant kinase, without interfering with the function of wild-type kinases whose ATP-binding pockets remain too small to accommodate the bulky analog. 3MB-PP1 is a bulky purine analog that acts as a selective, ATP-competitive, analog-sensitive polo-like kinase 1 (Plk1) allele inhibitor.3 At 10 µM, it can block mitotic progression in cells expressing analog-sensitive Plk1 alleles and has been used to selectively sensitize Plk1 to small-molecule inhibitors.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Cipak, L.,Zhang, C.,Kovacikova, I., et al. Generation of a set of conditional analog-sensitive alleles of essential protein kinases in the fission yeast Schizosaccharomyces pombe. Cell Cycle 10(20), 3527-3532 (2011).
2.Tay, Y.D.,Patel, A.,Kaemena, D.F., et al. Mutation of a conserved residue enhances the sensitivity of analogue-sensitised kinases to generate a novel approach to the study of mitosis in fission yeast. Journal of Cell Science 126(Pt 21), 5052-5061 (2013).
3.Burkard, M.E.,Santamaria, A. and Jallepalli, P.V. Enabling and disabling polo-like kinase 1 inhibition through chemical genetics. ACS Chemical Biology 7(6), 978-981 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 295.4 |
| 分子式 | C17H21N5 |
| CAS号 | 956025-83-5 |
| 稳定性 | ≥ 2 years |
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