NMS-873
货号：
17674-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 17674-1mg |
| 描述 | The p97 AAA (ATPase associated with diverse cellular activities) is a ubiquitin-selective chaperone known to play a critical role in the degradation of misfolded membrane and secretory proteins and has been linked to various cellular processes that require unfolding and disassembly of protein complexes.1 Valosin-containing protein (VCP), also known as VCP/p97, is an AAA ATPase family member that serves as an integral component of the ubiquitin fusion degradation pathway and is overexpressed in many tumor types. NMS-873 is a VCP inhibitor (IC50 = 24 nM) that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM).2 It has been shown to inhibit the proliferation of HCT116 cancer cells with an IC50 value of 380 nM.2 |
| 别名 | VCP Inhibitor III; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Chou, T.F. and Deshaies, R.J. Development of p97 AAA ATPase inhibitors. Autophagy 7(9), 1091-1092 (2011).
2.Polucci, P.,Magnaghi, P.,Angiolini, M., et al. Alkylsulfanyl-1,2,4-triazoles, a new class of allosteric valosine containing protein inhibitors. Synthesis and structure-activity relationships. Journal of Medicinal Chemistry 56(2), 437-450 (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 520.7 |
| 分子式 | C27H28N4O3S2 |
| CAS号 | 1418013-75-8 |
| 稳定性 | ≥ 2 years |
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