TAE684
货号：
17670-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 17670-1mg |
| 描述 | Human anaplastic lymphoma kinase (ALK) is an oncogene that is amplified in neuroblastomas and when juxtaposed with various fusion partners, its constitutive kinase activity is associated with the development of a type of anaplastic large cell lymphoma (ALCL).1,2 TAE684 is an ALK inhibitor that blocks the proliferation of ALCL-derived and ALK-dependent cell lines with IC50 values of 2-5 nM.1 When tested against a panel of 35 cells transformed by various tyrosine kinases, TAE684 demonstrated 100- to 1,000-fold selectivity for inhibiting ALK-driven cell proliferation.1 TAE684 treatment induces cell cycle arrest and apoptosis in ALK-dependent cell lines and has been used to suppress tumor growth in in vivo models of ALK-positive ALCL and neuroblastoma.1,2 TAE684 is also reported to inhibit the activity of the Parkinson’s disease-linked leucine-rich repeat kinase 2 (IC50s = 7.8 and 6.1 nM for wild-type and G2019S mutant LRRK2, respectively).3 |
| 别名 | NVP-TAE684; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Galkin, A.V.,Melnick, J.S.,Kim, S., et al. Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK. Proceedings of the National Academy of Sciences of the United States of America 104(1), 270-275 (2007).
2.Hasan, M.K.,Nafady, A.,Takatori, A., et al. ALK is a MYCN target gene and regulates cell migration and invasion in neuroblastoma. Sci.Rep. 3, (2013).
3.Zhang, J.,Deng, X.,Choi, H.G., et al. Characterization of TAE684 as a potent LRRK2 kinase inhibitor. Bioorganic & Medicinal Chemistry Letters 22(55), 1864-1869 (2012).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 614.2 |
| 分子式 | C30H40ClN7O3S |
| CAS号 | 761439-42-3 |
| 稳定性 | ≥ 2 years |
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