ML-347
货号：
17640-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 17640-1mg |
| 描述 | Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair.1 ML-347 is a 5-quinoline compound that inhibits ALK1 and ALK2 with IC50 values of 46 and 32 nM, respectively.2 It demonstrates >300-fold selectivity for ALK2 over ALK3, ALK6, and VEGF type 2 receptor (IC50s = 10.8, 9.8, and 19.7 µM, respectively) and is inactive at ALK4, ALK5, BMP type 2 receptors, TGF-β type 2 receptor, and AMPK.2 In a functional assay, ML-347 was shown to inhibit BMP4 signaling with an IC50 value of 152 nM.2 |
| 别名 | LDN193719; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Brivanlou, A.H. and Darnell, J.E., Jr. Signal transduction and the control of gene expression. Science 295, 813-818 (2002).
2.Engers, D.W.,Frist, A.Y.,Lindsley, C.W., et al. Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of Dorsomorphin: The discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorganic & Medicinal Chemistry Letters 23(11), 3248-3252 (2013).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 352.4 |
| 分子式 | C22H16N4O |
| CAS号 | 1062368-49-3 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
