| 货号 | 17503-1mg |
| 描述 | The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis.1 BGP-15 is a PARP inhibitor and insulin sensitizer. In perfused heart, it blocks self-ADP-ribosylation of nuclear PARP (Ki = 57 µM) and mono-ADP-ribosylation of GRP78, resulting in decreased levels of reactive oxygen species, lipid peroxidation, and single-strand DNA breaks.2,3 BGP-15 acts as a co-inducer of heat shock protein 72, augmenting expression induced by heat shock factor 1 in adipocytes and skeletal muscles and improving insulin sensitivity.4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Davar, D.,Beumer, J.H.,Hamieh, L., et al. Role of PARP inhibitors in cancer biology and therapy. Current Medicinal Chemistry 19(23), 3907-3921 (2012). 2.Halmosi, R.,Berente, Z.,Osz, E., et al. Effect of poly(ADP-ribose) polymerase inhibitors on the ischemia-reperfusion-induced oxidative cell damage and mitochondrial metabolism in langendorff heart perfusion system. Molecular Pharmaceutics 59(6), 1497-1505 (2001). 3.Szabados, E.,Literati-Nagy, P.,Farkas, B., et al. BGP-15, a nicotinic amidoxime derivate protecting heart from ischemia reperfusion injury through modulation of poly(ADP-ribose) polymerase. Biochemical Pharmacology 59(8), 937-945 (2000). 4.Chung, J.,Nguyen, A.K.,Henstridge, D.C., et al. HSP72 protects against obesity-induced insulin resistance. Proceedings of the National Academy of Sciences of the United States of America 105(5), 1739-1744 (2008). 5.Henstridge, D.C.,Bruce, C.R.,Drew, B.G., et al. Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance. Diabetes 63, 1881-1894 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 351.3 |
| 分子式 | C14H22N4O2 • 2HCl |
| CAS号 | 66611-37-8 |
| 稳定性 | ≥ 2 years |
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