GSK199 (hydrochloride)
货号：
17489-500ug 基本售价：
406.0 元 规格：
500 ug
产品信息
概述| 货号 | 17489-500ug |
| 描述 | Protein arginine deiminase 4 (PAD4) mediates the transformation of protein arginine into citrulline. Citrullination of proteins has normal roles in gene regulation and pathological roles in immunological and inflammatory diseases.1 GSK199 is a reversible inhibitor of PAD4 (IC50 = 200 nM) that binds to the low-calcium form of the enzyme and is selective for PAD4 over PAD1-3.2It is less potent than the related PAD4 inhibitor GSK484 (Item No. 17488), which demonstrates an IC50 value of 50 nM.2 GSK199 can inhibit the citrullination of PAD4 target proteins and diminish the formation of neutrophil extracellular traps in mouse neutrophils.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Jones, J.E.,Causey, C.P.,Knuckley, B., et al. Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential. Curr. Opin. Drug Discov. Devel. 12(5), 616-627 (2009).
2.Lewis, H.D.,Liddle, J.,Coote, J.E., et al. Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation. Nat. Chem. Biol. 11(3), 189-191 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 469 |
| 分子式 | C24H28N6O2 • HCl |
| CAS号 | 1549811-53-1 |
| 稳定性 | ≥ 2 years |
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