SAR260301
货号：
17391-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 17391-1mg |
| 描述 | SAR260301 is an inhibitor of phosphatidylinositol 3-kinase (PI3K) isoform β (IC50 = 52 nM).1 It is selective for p110β over other PI3K isoforms.1 SAR260301 demonstrates significant in vivo activity in a UACC-62 xenograft model in mice.1 It has synergistic antitumor activity when combined with the BRAF inhibitor vemurafenib (PLX4032; Item No. 10618) or the MEK inhibitor selumetinib (AZD 6244; Item No. 11599) in PTEN-deficient/BRAF-mutated human melanoma tumor models.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Certal, V.,Carry, J.C.,Halley, F., et al. Discovery and optimization of pyrimidone indoline amide PI3Kβ inhibitors for the treatment of phosphatase and tensin homologue (PTEN)-deficient cancers. J. Med. Chem. 57(3), 903-920 (2014).
2.Bonnevaux, H.,Lemaitre, O.,Vincent, L., et al. Concomitant inhibition of PI3Kβ and BRAF or MEK in PTEN-deficient/BRAF-mutant melanoma treatment: Preclinical assessment of SAR260301 oral PI3Kβ-selective inhibitor. Mol. Cancer Ther. 15(7), 1460-1471 (2016).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 354.4 |
| 分子式 | C19H22N4O3 |
| CAS号 | 1260612-13-2 |
| 稳定性 | ≥ 2 years |
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