NG 52
货号：
17309-500ug 基本售价：
406.0 元 规格：
500 ug
产品信息
概述| 货号 | 17309-500ug |
| 描述 | NG 52 is a tri-substituted purine that binds to the ATP-binding site of yeast cyclin-dependent kinases, inhibiting Cdc28p and Pho85p (IC50s = 7 and 2 µM, respectively).1 It is ineffective against the yeast kinases Kin28p, Srb10, and Cak1p. NG 52 is cell permeable and inhibits the growth of S. cerevisiae(GI50 = 30 µM).1 It is an analog of purvalanol A (Item No. 14579), a potent inhibitor of mammalian cyclin-dependent kinases.1 |
| 别名 | Compound 52; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Gray, N.S.,Wodicka, L.,Thunnissen, A.M.W.H., et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science 281, 533-538 (1998).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 346.8 |
| 分子式 | C16H19ClN6O |
| CAS号 | 212779-48-1 |
| 稳定性 | ≥ 2 years |
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