IMD 0354
货号：
17290-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 17290-1mg |
| 描述 | IMD 0354 is an IKKβ (IKK2) inhibitor that blocks NF-κB phosphorylation (IC50 = ~250 nM) and subsequent NF-κB p65 nuclear translocation.1 It exhibits cardioprotective properties by decreasing expression of P-selectin and ICAM-1 in the vasculature and blocking cardiomyocyte IL-1β and MCP-1 production, resulting in suppressed neutrophil accumulation in a rat model of ischemia/reperfusion injury.1 IMD 0354, suppresses the growth of human breast cancer cells by inducing cell cycle arrest and apoptosis.2 It induces apoptosis of chronic lymphocytic leukemia cells at 1-10 µM by directly targeting the NF-κB pathway, decreasing expression of anti-apoptotic genes and increasing expression of proapoptotic genes.3 |
| 别名 | IKK2 Inhibitor V; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Onai, Y.,Suzuki, J.i.,Kakuta, T., et al. Inhibition of IκB phosphorylation in cardiomyocytes attenuates myocardial ischemia/reperfusion injury. Cardiovascular Research 63(1), 51-59 (2004).
2.Tanaka, A.,Muto, S.,Konno, M., et al. A new IκB kinase β inhibitor prevents human breast cancer progression through negative regulation of cell cycle transition. Cancer Research 66(1), 419-426 (2006).
3.Kanduri, M.,Tobin, G.,Åleskog, A., et al. The novel NF-κB inhibitor IMD-0354 induces apoptosis in chronic lymphocytic leukemia. Blood Cancer J. 1(3), 1-6 (2011).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 383.7 |
| 分子式 | C15H8ClF6NO2 |
| CAS号 | 978-62-1 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
