VLX600
货号：
17192-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 17192-1mg |
| 描述 | VLX600 is a compound that shows selective cytotoxicity against quiescent cancer cells (IC50 = 1-10 µM) with selectivity for malignant cells.1 It induces necrosis in non-proliferating quiescent core cells in multicellular spheroids (MCs) formed from HCT116 colon cancer cells.1 VLX600 induces the expression of genes associated with hypoxia, glycolysis, and p53 signaling, stimulates autophagy, and triggers mitochondrial dysfunction in MCs.1 It displays antitumor activity against colon cancer xenografts with minimal systemic toxicity in mice.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Zhang, X.,Fryknäs, M.,Hernlund, E., et al. Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments. Nat.Commun. 5, 1-14 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 317.4 |
| 分子式 | C17H15N7 |
| CAS号 | 327031-55-0 |
| 稳定性 | ≥ 2 years |
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