Indoxyl Sulfate (potassium salt)
货号：
16926-100mg 基本售价：
406.0 元 规格：
100 mg
产品信息
概述| 货号 | 16926-100mg |
| 描述 | Indoxyl sulfate is a metabolite of tryptophan derived from dietary protein. Tryptophan is metabolized by intestinal bacteria into indole, which is absorbed into the blood and then further metabolized to indoxyl sulfate in the liver, which is normally excreted in urine. In chronic kidney disease patients where renal function is compromised, indoxyl sulfate can accumulate in serum as a uremic toxin, inducing oxidative stress and accelerating progression of the disease.1 Indoxyl sulfate at 250 µM can induce the activation of NF-κB, promoting the expression of both TGF-β1 and Smad3 expression in proximal tubular cells of rats, which is associated with profibrotic activity.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Niwa, T. Uremic toxicity of indoxyl sulfate. Nagoya J.Med.Sci. 72(1-2), 1-11 (2010).
2.Shimizu, H.,Yisireyili, M.,Nishijima, F., et al. Indoxyl sulfate enhances p53-TGF-β1-Smad3 pathway in proximal tubular cells. Am.J.Nephrol. 37(2), 97-103 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 251.3 |
| 分子式 | C8H6NO4S • K |
| CAS号 | 2642-37-7 |
| 稳定性 | ≥ 2 years |
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