| 货号 | 16885-50mg |
| 描述 | Evodiamine is a natural indole alkaloid found in the fruits of Wu Zhu Yu, a plant used in traditional Chinese medicine. Studies involving evodiamine have demonstrated beneficial effects in cancer, obesity, inflammation, and many other conditions.1,2,3 It can act as an aryl hydrocarbon antagonist (Ki = 28 nM), activator of the transient receptor potential vanilloid 1 channel (EC50 = 45 nM), and inhibit signaling through NF-κB.1,4,5 |
| 别名 | D-Evodiamine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Yu, H.,Gong, W.,Wang, Z., et al. Pharmacological actions of multi-target-directed evodiamine. Molecules 18(2), 1826-1843 (2013). 2.Wang, T.,Wang, X. and Yamashita, H. Evodiamine inhibits adipogenesis via the EGFR-PKCα-ERK signaling pathway. FEBS Letters 583(22), 3655-3659 (2009). 3.Ogasawara, M.,Matsubara, T. and Suzuki, H. Screening of natural compounds for inhibitory activity on colon cancer cell migration. Biological and Pharmaceutical Bullentin 24(6), 720-723 (2001). 4.Pearce, L.V.,Petukhov, P.A.,Szabo, T., et al. Evodiamine functions as an agonist for the vanilloid receptor TRPV1. Organic & Biomolecular Chemistry 2, 2281-2286 (2004). 5.Takada, Y.,Kobayashi, Y. and Aggarwal, B.B. Evodiamine abolishes constitutive and inducible NF-κB activation by inhibiting IκBα kinase activation, thereby suppressing NF-κB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion. The Journal of Biological Chemisty 280(17), 17203-17212 (2005). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 303.4 |
| 分子式 | C19H17N3O |
| CAS号 | 518-17-2 |
| 稳定性 | ≥ 2 years |
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