CAY10581
货号：
16838-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 16838-1mg |
| 描述 | The enzyme indoleamine 2,3-dioxygenase (IDO) has been implicated in mediating pathological immunosuppression associated with certain diseases, including cancer. Several naphthoquinones inhibit IDO in vitro and in cells, but at low (μM) potency.1 Importantly, naphthoquinones reduce tumor growth in wild type mice but not in IDO-deficient mice.1 CAY10581 is a naphthoquinone derivative that potently inhibits IDO (IC50 = 55 nM).1 It is a more potent inhibitor of IDO than annulin B or 1-methyl-d-tryptophan (1MT). CAY10581 acts as a reversible uncompetitive inhibitor of IDO and demonstrates minimal impact on cell viability at 100 μM after 24 hours.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kumar, S.,Malachowski, W.P.,DuHadaway, J.B., et al. Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. Journal of Medicinal Chemistry 51, 1706-1718 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 363.4 |
| 分子式 | C22H21NO4 |
| CAS号 | 1018340-07-2 |
| 稳定性 | ≥ 2 years |
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