| 货号 | 16753-1mg |
| 描述 | Deferasirox is a synthetic, tridentate iron-selective chelator that dramatically reduces iron in the liver and blood, particularly during transfusional iron overload.1 It is orally bioavailable, effectively reducing liver, serum, and cardiac iron concentrations in conditions requiring blood transfusions, including β-thalassemia, allogeneic stem cell transplantation, and anemias associated with hematopoietic malignancies.2,3,4,5 |
| 别名 | Exjade®;ICL670A; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hershko, C.,Konijn, A.M.,Nick, H.P., et al. ICL670A: A new synthetic oral chelator: Evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture. Blood 97(4), 1115-1122 (2001). 2.Cappellini, M.D.,Cohen, A.,Piga, A., et al. A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients withβthalassemia. Blood 107(9), 3455-3462 (2006). 3.Vallejo, C.,Batlle, M.,Vázquez, L., et al. Phase IV open-label study of the efficacy and safety of deferasirox after allogeneic stem cell transplantation. Haematologica 99(10), 1632-1637 (2014). 4.Kwiatkowski, J.L. Real-world use of iron chelators. Hematology Am.Soc.Hematol.Educ.Program 2011, 451-458 (2011). 5.Shah, J.,Kurtin, S.E.,Arnold, L., et al. Management of transfusion-related iron overload in patients with myelodysplastic syndromes. Clin.J.Oncol.Nurs. 16 Suppl, 37-46 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 373.4 |
| 分子式 | C21H15N3O4 |
| CAS号 | 201530-41-8 |
| 稳定性 | ≥ 2 years |
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