| 货号 | 16679-1mg |
| 描述 | Bone morphogenetic proteins (BMP) are secreted signaling proteins, many of which are involved in various developmental processes, in addition to bone formation.1 DMH1 is an analog of the non-selective BMP receptor inhibitor dorsomorphin (Item No. 11967) that potently inhibits the kinase activity of activin receptor-like kinase 2 (ALK2; IC50 = 13-108 nM).2,3 It is much less effective at ALK4, ALK5, AMPK, KDR (VEGFR2) or PDGFRβ, although it inhibits ALK1 and ALK3 at nanomolar concentrations.2,3 DMH1 is effective in vivo, as it disrupts dorsoventral development in zebrafish.2 It also affects stem cell development, increasing cardiomyocyte progenitors and promoting neurogenesis.4,5 DMH1 inhibits the growth of lung cancer cells, reducing tumor growth in a xenograft mouse model.6 |
| 别名 | BMP Inhibitor II;DorsoMorphin Homolog 1;VU036482; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Sakata, T. and Chen, J.K. Chemical Jekyll and Hyde’s: Small-molecule inhibitors of developmental signaling pathways. Chem.Soc.Rev. 40(8), 4318-4331 (2011). 2.Hao, J.,Ho, J.N.,Lewis, J.A., et al. In vivo structure activity relationship study of dorsomorphin analogs identifies selective VEGF and BMP inhibitors. ACS Chemical Biology 5(2), 245-253 (2010). 3.Mohedas, A.H.,Xing, X.,Armstrong, K.A., et al. Development of an ALK2-biased BMP type I receptor kinase inhibitor. ACS Chemical Biology 8(6), 1291-1302 (2013). 4.Ao, A.,Hao, J.,Hopkins, C.R., et al. DMH1, a novel BMP small molecule inhibitor, increases cardiomyocyte progenitors and promotes cardiac differentiation in mouse embryonic stem cells. PLoS One 7(7), 1-11 (2012). 5.Neely, M.D.,Litt, M.J.,Tidball, A.M., et al. DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: Comparison of PAX6 and SOX1 expression during neural induction. ACS Chem.Neurosci. 3, 482-491 (2012). 6.Hao, J.,Lee, R.,Chang, A., et al. DMH1, a small molecule inhibitor of BMP type I receptors, suppresses growth and invasion of lung cancer. PLoS One 9(3), 1-6 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 380.4 |
| 分子式 | C24H20N4O |
| CAS号 | 1206711-16-1 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |