| 货号 | 16674-25mg |
| 描述 | Flupirtine is an agonist of Kv7 potassium (KCNQ) channels, which are expressed predominantly in the nervous system but may also be found on smooth muscle and other sites.1,2 It doubles channel currents when applied at 10 µM.2 Through its effects on KCNQ channels, flupirtine serves as a centrally-acting analgesic with muscle tone-reducing activity.1,3 It is poorly metabolized by liver microsomal preparations and is, instead, targeted by peroxidases, including myeloperoxidase.3 Flupirtine also decreases neurotoxicity associated with prion disease, reducing cognitive decline in patients with Creutzfeldt-Jakob disease.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Brown, D.A. and Passmore, G.M. Neural KCNQ (Kv7) channels. British Journal of Pharmacology 156(8), 1185-1195 (2009). 2.Evseev, A.I.,Semenov, I.,Archer, C.R., et al. Functional effects of KCNQ K+ channels in airway smooth muscle. Front.Physiol. 4, 1-11 (2013). 3.Methling, K.,Reszka, P.,Lalk, M., et al. Investigation of the in vitro metabolism of the analgesic flupirtine. Drug Metabolism and Disposition 37(3), 479-493 (2009). 4.Appleby, B.S. and Lyketsos, C.G. Rapidly progressive dementias and the treatment of human prion diseases. Expert Opin.Pharmacother. 12(1), 1-12 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 420.4 |
| 分子式 | C15H17FN4O2 • C4H4O4 |
| CAS号 | 75507-68-5 |
| 稳定性 | ≥ 2 years |
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