| 货号 | 16471-50mg |
| 描述 | Danazol is a derivative of testosterone (Item No. 15645) and ethisterone that can bind to androgen receptors and sex hormone-binding globulin causing a 3-fold increase in free testosterone.1,2,3 It possesses weak androgenic effects and inhibits the production of gonadotropins.4 It has been used to address symptoms of endometriosis and to inhibit the growth of endocrine-responsive pancreatic and breast cancer cells but has also been linked to the development of ovarian cancer.2,4,5 |
| 别名 | Danocrine;Ladogal;NSC 270916;WIN 17,757; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ma, R.,Cotton, B.,Lichtensteiger, W., et al. UV filters with antagonistic action at androgen receptors in the MDA-kb2 cell transcriptional-activation assay. Toxicological Sciences 74, 43-50 (2003). 2.Cottreau, C.M.,Ness, R.B.,Modugno, F., et al. Endometriosis and its treatment with danazol or lupron in relation to ovarian cancer. Clinical Cancer Research 9(14), 5142-5144 (2003). 3.Haning, R.V., Jr.,Carlson, I.H.,Cortes, J., et al. Danazol and its principal metabolites interfere with binding of testosterone, cortisol, and thyroxin by plasma proteins. Clinical Chemistry 28(4 Pt 1), 696-698 (1982). 4.Peters, T.G.,Lewis, J.D.,Wilkinson, E.J., et al. Danazol therapy in hormone-sensitive mammary carcinoma. Cancer 40(6), 2797-2800 (1977). 5.Benz, C.,Hollander, C. and Miller, B. Endocrine-responsive pancreatic carcinoma: Steroid binding and cytotoxicity studies in human tumor cell lines. Cancer Research 46(5), 2276-2281 (1986). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 337.5 |
| 分子式 | C22H27NO2 |
| CAS号 | 17230-88-5 |
| 稳定性 | ≥ 2 years |
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