| 货号 | 16462-1mg |
| 描述 | Azumolene is a muscle relaxant that inhibits the release of calcium from skeletal muscle sarcoplasmic reticulum.1,2 It inhibits a component of store-operated calcium entry (SOCE) that is coupled to the skeletal muscle ryanodine receptor, with 20 µM azumolene causing a 70% reduction in SOCE in myotubes.3,4 Azumolene has utility in countering muscle dysfunction associated with malignant hyperthermia.4 |
| 别名 | EU4093; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Palnitkar, S.S.,Michelson, J.R.,Louis, C.F., et al. Pharmacological distinction between dantrolene and ryanodine binding sites: Evidence from normal and malignant hyperthermia-susceptible porcine skeletal muscle. Biochemistry Journal 326, 847-852 (1997). 2.Leslie, G.C. and Part, N.J. The effect of EU4093 (azumolene sodium) on the contraction of intrafusal muscle in the soleus muscle of the anaesthetized rat. British Journal of Pharmacology 97(4), 1151-1156 (1989). 3.Zhao, X.,Weisleder, N.,Han, X., et al. Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal muscle ryanodine receptor. The Journal of Biological Chemisty 281(44), 33477-33486 (2006). 4.Yarotskyy, V.,Protasi, F. and Dirksen, R.T. Accelerated activation of SOCE current in myotubes from two mouse models of anesthetic- and heat-induced sudden death. PLoS One 8(10), 1-12 (2013). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 371.1 |
| 分子式 | C13H8BrN4O3 • Na |
| CAS号 | 105336-14-9 |
| 稳定性 | ≥ 2 years |
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