| 货号 | 16456-250mg |
| 描述 | Indoleamine 2,3-dioxygenase (IDO) metabolizes tryptophan to kynurenine, leading to the production of NAD+via the kynurenine pathway. The overexpression of IDO in tumors and tumor-draining lymph nodes induces immune tolerance and enhances tumor growth in vivo.1,2 1-methyl-D-Tryptophan is an inhibitor of IDO (IC50 = 7 µM) that is effective in vivo.3,4 In mice, 1-methyl-D-tryptophan prevents T-cell anergy triggered by dendritic cells overexpressing IDO.4 It augments the antitumor and antiviral immunoresponse of CD8+ T-cells and reduces tumor volume in mice with xenografts overexpressing IDO.1,2 1-methyl-D-Tryptophan, in combination with chemotherapy, causes regression of tumors and prolongs survival.1,5 Surprisingly, 1-methyl-D-tryptophan induces the expression of IDO in human ovarian carcinoma SKOV3 cells in culture.5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Yoshida, N.,Ino, K.,Ishida, Y., et al. Overexpression of indoleamine 2,3-dioxygenase in human endometrial carcinoma cells induces rapid tumor growth in a mouse xenograft model. Clinical Cancer Research 14(22), 7251-7259 (2008). 2.Rytelewski, M.,Meilleur, C.E.,Yekta, M.A., et al. Suppression of immunodominant antitumor and antiviral CD8+ T cell responses by indoleamine 2,3-dioxygenase. PLoS One 9(2), 1-15 (2014). 3.Dolusic, E.,Larrieu, P.,Blanc, S., et al. Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors. European Journal of Medicinal Chemistry 46(7), 3058-3065 (2011). 4.Munn, D.H.,Sharma, M.D.,Hou, D., et al. Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes. Journal of Clinical Investigation 114(2), 280-290 (2004). 5.Opitz, C.A.,Litzenburger, U.M.,Opitz, U., et al. The indoleamine-2,3-dioxygenase (IDO) inhibitor 1-methyl-D-tryptophan upregulates IDO1 in human cancer cells. PLoS One 6(5), 1-11 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 218.3 |
| 分子式 | C12H14N2O2 |
| CAS号 | 110117-83-4 |
| 稳定性 | ≥ 2 years |
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