| 货号 | 16408-500mg |
| 描述 | 2-Deoxyguanosine 5-monophosphate (dGMP) is used as a substrate of guanylate kinases to generate dGDP, which in turn is phosphorylated to dGTP, a nucleotide precursor used in DNA synthesis. In addition, dGMP can be efficiently phosphorylated by the type I thymidylate kinase of the malarial agent P. falciparum.1,2 In humans, deficiency of mitochondrial deoxyguanosine kinase, which synthesizes dGMP from ATP and deoxyguanosine, contributes to mitochondrial DNA depletion syndrome.3,4 |
| 别名 | dGMP; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kandeel, M.,Kitamura, Y. and Kitade, Y. The exceptional properties of Plasmodium deoxyguanylate pathways as a potential area for metabolic and drug discovery studies. Nucleic Acids Symp.Ser.(Oxf) 53, 39-40 (2009). 2.Whittingham, J.L.,Carrero-Lerida, J.,Brannigan, J.A., et al. Structural basis for the efficient phosphorylation of AZT-MP (3-azido-3-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinase. Biochemistry Journal 428(3), 499-509 (2014). 3.Taanman, J.W.,Muddle, J.R. and Muntau, A.C. Mitochondrial DNA depletion can be prevented by dGMP and dAMP supplementation in a resting culture of deoxyguanosine kinase-deficient fibroblasts. Human Molecular Genetics 12(15), 1839-1845 (2003). 4.Bulst, S.,Abicht, A.,Holinski-Feder, E., et al. In vitro supplementation with dAMP/dGMP leads to partial restoration of mtDNA levels in mitochondrial depletion syndromes. Human Molecular Genetics 18(9), 1590-1599 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 391.2 |
| 分子式 | C10H12N5O7P • 2Na [XH2O] |
| CAS号 | 146877-98-7 |
| 稳定性 | ≥ 2 years |
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