| 货号 | 16354-500ug |
| 描述 | SU 1498 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM), having negligible activity at several other serine/threonine and tyrosine kinases.1,2 It effectively blocks signaling through VEGFR2 both in vitroandin vivo.1,3 SU 1498 is used to study the role of VEGFR2 signaling in diverse processes, including angiogenesis, tumor growth, neural progenitor cell survival, and neuroregeneration.3,4,5,6 |
| 别名 | AG-1498;Tyrphostin SU 1498; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Strawn, L.M.,McMahon, G.,App, H., et al. Flk-1 as a target for tumor growth inhibition. Cancer Research 56(15), 3540-3545 (1996). 2.Fedorov, O.,Marsden, B.,Pogacic, V., et al. A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proceedings of the National Academy of Sciences of the United States of America 104(51), 20523-20528 (2007). 3.Arbiser, J.L.,Larsson, H.,Claesson-Welsh, L., et al. Overexpression of VEGF 121 in immortalized endothelial cells causes conversion to slowly growing angiosarcoma and high level expression of the VEGF receptors VEGFR-1 and VEGFR-2 in vivo. American Journal of Pathology 156(4), 1469-1476 (2000). 4.Francescone, R.,Scully, S.,Bentley, B., et al. Glioblastoma-derived tumor cells induce vasculogenic mimicry through Flk-1 protein activation. The Journal of Biological Chemisty 287(29), 24821-24831 (2012). 5.Harms, K.M.,Li, L. and Cunningam, L.A. Murine neural stem/progenitor cells protect neurons against ischemia by HIF-1α-regulated VEGF signaling. PLoS One 5(3), 1-12 (2010). 6.Pan, Z.,Fukuoka, S.,Karagianni, N., et al. Vascular endothelial growth factor promotes anatomical and functional recovery of injured peripheral nerves in the avascular cornea. FEBS Journal 27(7), 2756-2767 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 390.5 |
| 分子式 | C25H30N2O2 |
| CAS号 | 168835-82-3 |
| 稳定性 | ≥ 2 years |
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