| 货号 | 16337-500ug |
| 描述 | SB-3CT is a selective, mechanism-based inhibitor of the gelatinases, matrix metalloproteinase-2 (MMP-2) and MMP-9 (Kis = 28 and 400 nM, respectively).1,2 First pass metabolism of SB-3CT in vivo produces a monohydroxylated metabolite that has greater inhibitory activity (Kis = 6 and 160 nM for MMP-2 and MMP-9, respectively).2 Both SB-3CT and its active metabolite can cross the blood-brain barrier and have utility in diseases of the central nervous system, such as stroke and traumatic brain injury.2,3 SB-3CT may have applications in other pathologies involving gelatinases, including cancer, cardiovascular diseases, and inflammation.4,5 |
| 别名 | Matrix Metalloproteinase-2/9 Inhibitor IV;MMP-2/MMP-9 Inhibitor IV; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kleifeld, O.,Kotra, L.P.,Gervasi, D.C., et al. X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor. Comparison with the latent and active forms of the enzyme. The Journal of Biological Chemisty 276(20), 17125-17131 (2001). 2.Gooyit, M.,Suckow, M.A.,Schroeder, V.A., et al. Selective gelatinase inhibitor neuroprotective agents cross the blood-brain barrier. ACS Chem.Neurosci. 3(10), 730-736 (2012). 3.Hadass, O.,Tomlinson, B.N.,Gooyit, M., et al. Selective inhibition of matrix metalloproteinase-9 attenuates secondary damage resulting from severe traumatic brain injury. PLoS One 8(10), e76904 (2013). 4.Krüger, A.,Arlt, M.J.,Gerg, M., et al. Antimetastatic activity of a novel mechanism-based gelatinase inhibitor. Cancer Research 65(9), 3523-3526 (2005). 5.Gooyit, M.,Lee, M.,Schroeder, V.A., et al. Selective water-soluble gelatinase inhibitor prodrugs. Journal of Medicinal Chemistry 54(19), 6676-6690 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 306.4 |
| 分子式 | C15H14O3S2 |
| CAS号 | 292605-14-2 |
| 稳定性 | ≥ 2 years |
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