PBIT
货号：
16272-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 16272-1mg |
| 描述 | Jumonji AT-rich interactive domain 1 (JARID1) demethylases mediate the removal of methyl groups from trimethylated lysine 4 on histone 3 (H3K4me3). PBIT is a reversible, cell-permeable inhibitor of JARID1 family demethylases (IC50s = 6, 3, 4.9, and 28 µM for JARID1A, JARID1B, JARID1C, and JARID1D, respectively).1 It does not significantly affect the activity of UTX and JMJD3 demethylases.1 It increases trimethylation of H3K4 in HeLa cells and blocks the proliferation of tumor cells expressing high levels of JARID1B.1 |
| 别名 | 2-p-tolyl-1,2-Benzisothiazolin-3-one; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sayegh, J.,Cao, J.,Zou, M.R., et al. Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen. The Journal of Biological Chemisty 288(13), 9408-9417 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 241.3 |
| 分子式 | C14H11NOS |
| CAS号 | 2514-30-9 |
| 稳定性 | ≥ 2 years |
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