Chlorthalidone
货号：
16213-5mg 基本售价：
406.0 元 规格：
5 mg
产品信息
概述| 货号 | 16213-5mg |
| 描述 | Chlorthalidone is a nonthiazide diuretic that inhibits the sodium/chloride cotransporter in the distal convoluted tubule of the kidney, which prevents reabsorption of sodium and chloride leading to a reduction in plasma volume and cardiac output.1 It also effectively inhibits the activity of most platelet carbonic anhydrase isozymes (IC50s = 2.8 nM - 11 µM), which has been attributed to the sustained vasodilator capability of this compound.2 Chlorthalidone has been used independently or in combination with other antihypertensive agents to lower arterial blood pressure, and also as an adjuvant to address edema caused by cardiac or renal disorders.3 |
| 别名 | Hygroton;NSC 69200;Oradil;Thalitone®; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Roush, G.C.,Holford, T.R. and Guddati, A.K. Chlorthalidone compared with hydrochlorothiazide in reducing cardiovascular events: Systematic review and network meta-analyses. Hypertension 59(6), 1110-1117 (2012).
2.Woodman, R.,Brown, C. and Lockette, W. Chlorthalidone decreases platelet aggregation and vascular permeability and promotes angiogenesis. Hypertension 56(3), 463-470 (2010).
3.Reyes, A.J. Diuretics in the therapy of hypertension. J. Hum. Hypertens. 16, 78-83 (2002).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 338.8 |
| 分子式 | C14H11ClN2O4S |
| CAS号 | 77-36-1 |
| 稳定性 | ≥ 2 years |
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