| 货号 | 16134-5mg |
| 描述 | Bisphosphonates bind strongly to bone and reduce bone resorption through effects on both osteoclasts and osteoblasts.1,2 Clodronate is a non-nitrogenous bisphosphonate that has been used in the treatment of osteoporosis and other metabolic bone diseases. It binds to hydroxyapatite crystals with an affinity constant of 0.72 µM, inhibiting their growth (IC50 = 1.34 µM) and bone resorption.3 Clondronate is metabolized intracellularly to a β-γ-methylene analog of ATP that is cytotoxic to both osteoclasts and macrophages, which belong to the same cell lineage as osteoclasts.4 Liposome-encapsulated bisphosphonates such as clodronate have been used in biological research to selectively deplete macrophage-like cells and cancer cells.5 |
| 别名 | Clodronic acid; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Sahni, M.,Guenther, H.L.,Fleisch, H., et al. Bisphosphonates act on rat bone resorption through the mediation of osteoblasts. Journal of Clinical Investigation 91, 2004-2011 (1993). 2.Bell, N.H. and Johnson, R.H. Bisphosphonates in the treatment of osteoporosis. Endocrine 6(2), 203-206 (1997). 3.Nancollas, G.H.,Tang, R.,Phipps, R.J., et al. Novel insights into actions of bisphosphonates on bone: Differences in interactions with hydroxyapatite. Bone 38(5), 617-627 (2006). 4.Lehenkari, P.P.,Kellinsalmi, M.,Näpänkangas, J.P., et al. Further insight into mechanism of action of clodronate: Inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite. Molecular Pharmacology 61(5), 1255-1262 (2002). 5.Sabatino, R.,Antonelli, A.,Battistelli, S., et al. Macrophage depletion by free bisphosphonates and zoledronate-loaded red blood cells. PLoS One 9(6), e101260 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 360.9 |
| 分子式 | CH2Cl2O6P2 • 2Na [4H2O] |
| CAS号 | 88416-50-6 |
| 稳定性 | ≥ 6 months |
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