| 货号 | 16076-5mg |
| 描述 | Calmodulin is a calcium-dependent protein that regulates the activity of a diverse array of enzymes, ion channels, and other proteins and thus has diverse roles in cell function.1,2 A-7 is an analog of the napthalenesulfonamide W-7 (Item No. 14826) that has an acyl chain length of 10 carbons, rather than six. It is a potent cell-permeable antagonist of calmodulin that inhibits Ca2+/calmodulin cyclic nucleotide phosphodiesterase more potently than W-7 (IC50 = 3.2 and 26 µM, respectively).3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Benaim, G. and Villalobo, A. Phosphorylation of calmodulin. Functional implications. European Journal of Biochemistry 269(15), 3619-3631 (2002). 2.Chin, D. and Means, A.R. Calmodulin: A prototypical calcium sensor. Trends in Cell Biology 10(8), 322-328 (2000). 3.Hidaka, H. and Tanaka, T. Naphthalenesulfonamides as calmodulin antagonists. Methods in Enzymology 102, 185-194 (1983). 4.Itoh, H. and Hidaka, H. Direct interaction of calmodulin antagonists with Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase. Journal of Biochemistry 96(6), 1721-1726 (1984). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 433.4 |
| 分子式 | C20H29ClN2O2S • HCl |
| CAS号 | 79127-24-5 |
| 稳定性 | ≥ 2 years |
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