Remodelin (hydrobromide)
货号：
16066-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 16066-1mg |
| 描述 | Progeria is a genetic disorder that results in the appearance of premature aging. Genetically, progeria is characterized by a mutation in lamin A, which results in misshapen cell nuclei and DNA damage. Remodelin is a 2-thiazolylhydrazone derivative that, at 10 µM, improves nuclear architecture, chromatin organization, and survival of both cells lacking lamin A and cells from patients with progeria.1 Remodelin is an inhibitor of N-acetyltransferase 10 (NAT10), which acetylates both histones and microtubules.1 Mutation of NAT10 mimics the effects of remodelin on nuclear morphology, suggesting that these effects of remodelin require NAT10.1 Remodelin also has cytotoxic effects against some species of the fungus Candida.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Larrieu, D.,Britton, S.,Demir, M., et al. Chemical inhibition of NAT10 corrects defects of laminopathic cells. Science 344(6183), 527-532 (2014).
2.Chimenti, F.,Bizzarri, B.,Maccioni, E., et al. Synthesis and in vitro activity of 2-thiazolylhydrazone derivatives compared with the activity of clotrimazole against clinical isolates of Candida spp. Bioorganic & Medicinal Chemistry Letters 17(16), 4635-4640 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 363.3 |
| 分子式 | C15H14N4S • HBr |
| CAS号 | 1622921-15-6 |
| 稳定性 | ≥ 2 years |
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