Zoniporide (hydrochloride)
货号：
16004-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 16004-1mg |
| 描述 | The sodium-hydrogen exchanger isoform-1 (NHE-1) is the most predominant isoform of the Na+/H+ exchanger and is expressed in the heart where it contributes to cardiomyocyte pH homeostasis.1 It plays an important role in the myocardial response to ischemia-reperfusion. Zoniporide inhibits human NHE-1 with an IC50 value of 14 nM, displaying greater than 150-fold selectivity over other NHE isoforms.2 It has been shown to reduce infarct size in a rabbit myocardial ischemia-reperfusion model without adversely affecting hemodynamics or cardiac function.1 In isolated heart, zoniporide reduced infarct size with an EC50 value of 0.25 nM.2 |
| 别名 | CP 597,396; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Masereel, B.,Pochet, L. and Laeckmann, D. An overview of inhibitors of Na+/H+ exchanger. Eur. J. Med. Chem. 38(6), 547-554 (2003).
2.Tracey, W.R.,Allen, M.C.,Frazier, D.E., et al. Zoniporide: A potent and selective inhibitor of the human sodium-hydrogen exchanger isoform 1 (NHE-1). Cardiovascular Drug Reviews 21(1), 17-32 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 393.3 |
| 分子式 | C17H16N6O • HCl |
| CAS号 | 241800-97-5 |
| 稳定性 | ≥ 2 years |
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