| 货号 | 15954-1mg |
| 描述 | Amodiaquine is an aminoquinoline antimalarial compound.1 It is metabolized primarily by cytochrome P450 2C8 to N-desethylaminodiaquine, which is highly active against P. falciparum and can synergize with amodiaquine.2,3 Amodiaquine is commonly used in combination therapy.1,4 |
| 别名 | Camoquine;Flavoquine;NSC 13453;SN 10751; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Sá, J.M.,Chong, J.L. and Wellems, T.E. Malaria drug resistance: New observations and developments. Essays in Biochemistry 51, 137-160 (2014). 2.Li, X.Q.,Björkman, A.,Andersson, T.B., et al. Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: A new high affinity and turnover enzyme-specific probe substrate. Journal of Pharmacology and Experimental Therapeutics 300(2), 399-407 (2002). 3.Mariga, S.T.,Gil, J.P.,Sisowath, C., et al. Synergism between amodiaquine and its major metabolite, desethylamodiaquine, against Plasmodium falciparum in vitro. Antimicrobial Agents and Chemotherapy 48(11), 4089-4096 (2004). 4.Hwang, J.,Bitarakwate, E.,Pai, M., et al. Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for uncomplicated malaria: A systematic review. Trop.Med.Int.Health 11(6), 789-799 (2006). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 355.9 |
| 分子式 | C20H22ClN3O |
| CAS号 | 86-42-0 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |