| 货号 | 15888-1g |
| 描述 | Doxepin is a tricyclic antidepressant that inhibits the reuptake of serotonin (Item No. 14332) and norepinephrine and acts as an antagonist at histamine, serotonin, adrenergic, and muscarinic receptors with Ki values in the nanomolar range.1,2,3,4,5,6 |
| 别名 | Sinequan; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Booth, R.G.,Moniri, N.H.,Bakker, R.A., et al. A novel phenylaminotetralin radioligand reveals a subpopulation of histamine H1 receptors. Journal of Pharmacology and Experimental Therapeutics 302(1), 328-336 (2002). 2.Cusack, B.,Nelson, A. and Richelson, E. Binding of antidepressants to human brain receptors: Focus on newer generation compounds. Psychopharmacology (Berl) 114(4), 559-565 (1994). 3.de Graaf, C.,Kooistra, A.J.,Vischer, H.F., et al. Crystal structure-based virtual screening for fragment-like ligands of the human histamine H1 receptor. Journal of Medicinal Chemistry 54(23), 8195-8206 (2011). 4.Pälvimäki, E.P.,Roth, B.L.,Majasuo, H., et al. Interactions of selective serotonin reuptake inhibitors with the serotonin 5-HT2C receptor. Psychopharmacology (Berl) 126(3), 234-240 (1996). 5.Stanton, T.,Bolden-Watson, C.,Cusack, B., et al. Antagonism of the five cloned human muscarinic cholinergic receptors expressed in CHO-K1 cells by antidepressants and antihistaminics. Biochemical Pharmacology 45(11), 2352-2354 (1993). 6.Tatsumi, M.,Groshan, K.,Blakely, R.D., et al. Pharmacological profile of antidepressants and related compounds at human monoamine transporters. European Journal of Pharmacology 340(2-3), 249-258 (1997). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 315.8 |
| 分子式 | C19H21NO • HCl |
| CAS号 | 1229-29-4 |
| 稳定性 | ≥ 2 years |
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