| 货号 | 15884-1g |
| 描述 | Clomipramine is a tricyclic antidepressant, the 3-chlorinated derivative of imipramine (Item No. 15890).1 Like imipramine, clomipramine potently inhibits serotonin and norepinephrine reuptake (Kis = 7.4 and 96 nM, respectively).2,3 It also is an antagonist at histamine, muscarinic acetylcholine, α1-adrenergic, and dopamine receptors (Kds = 31, 37, 38, and 190 nM for H1, M1, α1, and D2, respectively).4 |
| 别名 | Anafranil; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Spencer, P.S. Review of the pharmacology of existing antidepressants. British Journal of Clinical Pharmacology 4(Suppl 2), 57S-68S (1977). 2.Hrdina, P.D. Pharmacology of serotonin uptake inhibitors: Focus on fluvoxamine. J.Psychiatry Neurosci. 16(2 Suppl. 1), 10-18 (1991). 3.Tatsumi, M.,Groshan, K.,Blakely, R.D., et al. Pharmacological profile of antidepressants and related compounds at human monoamine transporters. European Journal of Pharmacology 340(2-3), 249-258 (1997). 4.Richelson, E. and Nelson, A. Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro. Journal of Pharmacology and Experimental Therapeutics 230(1), 94-102 (1984). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 351.3 |
| 分子式 | C19H23ClN2 • HCl |
| CAS号 | 17321-77-6 |
| 稳定性 | ≥ 2 years |
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