| 货号 | 15622-5mg |
| 描述 | GBR 12909 is a potent inhibitor that blocks dopamine uptake (IC50 = 1-51 nM).1,2 It is more than 100-fold less effective at blocking serotonin or noradrenaline uptake.1,2 GBR 12909 effectively inhibits dopamine uptake in vivo, leading to consequent stimulation of dopamine receptors.1,3 GBR 12909 also inhibits pyrilamine binding to the histamine H1 receptor (IC50 = 18 nM) but poorly inhibits ligand binding to dopamine, adrenergic, acetylcholine, serotonin, and γ-aminobutyric acid receptors.2 It also blocks ligand binding to sigma receptors in rat brain (IC50 = 48 nM).4 |
| 别名 | I 893; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Heikkila, R.E. and Manzino, L. Behavioral properties of GBR 12909, GBR 13069 and GBR 13098: Specific inhibitors of dopamine uptake. European Journal of Pharmacology 103(3-4), 241-248 (1984). 2.Andersen, P.H. The dopamine uptake inhibitor GBR 12909: Selectivity and molecular mechanism of action. European Journal of Pharmacology 166(3), 493-504 (1989). 3.Melia, K.F. and Spealman, R.D. Pharmacological characterization of the discriminative-stimulus effects of GBR 12909. Journal of Pharmacology and Experimental Therapeutics 258(2), 626-632 (1991). 4.Contreras, P.C.,Bremer, M.E. and Rao, T.S. GBR-12909 and fluspirilene potently inhibited binding of [3H](+)3-PPP to sigma receptors in rat brain. Life Sciences 47(22), PL133-PL137 (1990). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 523.5 |
| 分子式 | C28H32F2N2O • 2HCl |
| CAS号 | 67469-78-7 |
| 稳定性 | ≥ 2 years |
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