| 货号 | 15517-10g |
| 描述 | 2-Thenoyltrifluoroacetone (TTFA) is an inhibitor of respiration in animals and bacteria. In animals, TTFA binds at the quinone reduction site of succinate:ubiquinone oxidoreductase (SQR; Complex II), preventing ubiquinone from binding.1,2 It inhibits NADH fumarate reductase in bacteria.3,4 TTFA also inhibits photosystem II in plants and NADH-ubiquinone oxidoreductase of the virus Vibrio cholerae, decreasing cholera toxin production.5,6 This compound is also a chelator of metals, including lanthanum, zirconium, hafnium, and neodymium. |
| 别名 | NSC 66544;NSC 405702;NSC 405703;NSC 405704;NSC 405705;NSC 405706;TTFA; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Sun, F.,Huo, X.,Zhai, Y., et al. Crystal structure of mitochondrial respiratory membrane protein complex II. Cell 121, 1043-1057 (2005). 2.Horsefield, R.,Yankovskaya, V.,Sexton, G., et al. Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): A mechanism of electron transfer and proton conduction during ubiquinone reduction. The Journal of Biological Chemisty 281(11), 7309-7316 (2006). 3.Yankovskaya, V.,Sablin, S.O.,Ramsay, R.R., et al. Inhibitor probes of the quinone binding sites of mammalian complex II and Escherichia coli fumarate reductase. The Journal of Biological Chemisty 271(35), 21020-21024 (1996). 4.Chen, M.,Andersen, L.P.,Zhai, L., et al. Characterization of the respiratory chain of Helicobacter pylori. FEMS Immunology and Medical Microbiology 24, 169-174 (1999). 5.Ikezawa, N.,Ifuku, K.,Endo, T., et al. Inhibition of photosystem II of spinach by the respiration inhibitors piericidin A and thenoyltrifluoroacetone. Bioscience, Biotechnology, and Biochemistry 66(9), 1925-1929 (2002). 6.Minato, Y.,Fassio, S.R.,Reddekopp, R.L., et al. Inhibition of the sodium-translocating NADH-ubiquinone oxidoreductase [Na+-NQR] decreases cholera toxin production in Vibrio cholerae O1 at the late exponential growth phase. Microb.Pathog. 66, 36-39 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 222.2 |
| 分子式 | C8H5F3O2S |
| CAS号 | 326-91-0 |
| 稳定性 | ≥ 2 years |
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