| 货号 | 15413-1mg |
| 描述 | (S)-MG115 is a potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (Ki = 21 nM).1 It reduces the degradation of ubiquitin-conjugated proteins in extracts.1 (S)-MG115 also blocks the degradation of long- and short-lived proteins in intact cells as well as the proteolytic generation of diverse proteins, including NF-κB, antigens, and p53.1,2,3 Proteasome inhibitors, including (S)-MG115, can induce a heat shock response and apoptosis, particularly in cancer cells.3,4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Rock, K.L.,Gramm, C.,Rothstein, L., et al. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78, 761-771 (1994). 2.Palombella, V.J.,Rando, O.J.,Goldberg, A.L., et al. The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB. Cell 78(5), 773-785 (1994). 3.Lopes, U.G.,Erhardt, P.,Yao, R., et al. p53-dependent induction of apoptosis by proteasome inhibitors. The Journal of Biological Chemisty 272(20), 12893-12896 (1997). 4.Bush, K.T.,Goldberg, A.L. and Nigam, S.K. Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance. The Journal of Biological Chemisty 272(14), 9086-9092 (1997). 5.Gartel, A.L. A new target for proteasome inhibitors: FoxM1. Expert Opinion on Investigational Drugs 19(2), 235-242 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 461.6 |
| 分子式 | C25H39N3O5 |
| CAS号 | 133407-86-0 |
| 稳定性 | ≥ 2 years |
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