PPACKII (trifluoroacetate salt)
货号：
15360-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 15360-1mg |
| 描述 | Kallikreins are a class of serine proteases that affect the release of vasodepressor peptides or kinins from a plasma substrate. PPACKII is a specific and irreversible inhibitor of glandular and plasma kallikreins.1 At micromolar concentrations it has been shown to prevent apolipoprotein proteolysis in dextran sulfate-precipitated human plasma LDL and to inhibit serum atrial natriuretic peptide cleavage.2 PPACKII has also been reported to inactivate the amidolytic activity of native human Hageman Factor (Factor XII) at 5.3 μM.3 |
| 别名 | H-D-Phe-Phe-Arg-Chloromethyl Ketone; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kettner, C. and Shaw, E. Inactivation of trypsin-like enzymes with peptides of arginine chloromethyl ketone. Methods in Enzymology 80(C), 826-842 (1981).
2.Byrne, R.E. and Scanu, A.M. Apolipoprotein B-100 of plasma low density lipoproteins undergoes proteolysis by contact activation factors when plasma is treated with dextran sulfate-500-MgCl2. Journal of Lipid Research 30, 109-120 (1989).
3.Silverberg, M. and Kaplan, A.P. Enzymatic activities of activated and zymogen forms of human Hageman factor (factor XII). Blood 60(1), 64-70 (1982).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 729.1 |
| 分子式 | C25H33ClN6O3 • 2CF3COOH |
| CAS号 | 649748-23-2 |
| 稳定性 | ≥ 2 years |
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