Atglistatin
货号：
15284-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 15284-1mg |
| 描述 | Adipose triglyceride lipase (ATGL or PNPLA2) catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets, generating diacylglyerol.1,2 Atglistatin is a potent, selective, and competitive inhibitor of ATGL (IC50 = 0.7 μM).3 It does not inhibit hormone-sensitive lipase, monoglyceride lipase, pancreatic lipase, lipoprotein lipase, or other lysophospholipases.3 Atglistatin blocks lipolysis by ATGL in vitro, in white adipose tissue organ cultures, and in vivo.3 It does not affect lipolysis in ATGL knockout mice.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lass, A.,Zimmermann, R.,Oberer, M., et al. Lipolysis - a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores. Progress in Lipid Research 50, 14-27 (2011).
2.Watt, M.J. and Spriet, L.L. Triacylglycerol lipases and metabolic control: Implications for health and disease. American Journal of Physiology.Endocrinology and Metabolism 299, E162-E168 (2010).
3.Mayer, N.,Schweiger, M.,Romauch, M., et al. Development of small-molecule inhibitors targeting adipose triglyceride lipase. Nature Chemical Biology 9(12), 785-787 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 283.4 |
| 分子式 | C17H21N3O |
| CAS号 | 1469924-27-3 |
| 稳定性 | ≥ 2 years |
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