CID16020046
货号：
15247-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 15247-1mg |
| 描述 | GPR55 is a G protein-coupled receptor (GPCR) that is weakly activated by some cannabinoids (CBs) at nM concentrations but displays a 5- to 10-fold greater stimulation in response to 1 µM lysophosphatidylinositol (LPI).1,2 CID16020046 is a GPR55 inverse agonist that antagonizes GPR55 constitutive activity with an IC50 value of 15 μM.3 It inhibits GPR55-mediated ERK1/2 phosphorylation, LPI-induced Ca2+ signaling (IC50 = 0.21 μM in HEK-GPR55 cells), and GPR55-mediated transcription factor activation.3 It does not affect ERK1/2 phosphorylation or transcription factor activation in CB receptor expressing cells and demonstrates weak activity against a broad spectrum of other GPCRs, ion channels, kinases, and nuclear receptors.3 This compound has been shown to block GPR55-mediated endothelial wound healing and reverse LPI-inhibited platelet aggregation.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ryberg, E.,Larsson, N.,Sjögren, S., et al. The orphan receptor GPR55 is a novel cannabinoid receptor. British Journal of Pharmacology 152, 1092-1101 (2007).
2.Oka, S.,Nakajima, K.,Yamashita, A., et al. Identification of GPR55 as a lysophosphatidylinositol receptor. Biochemical and Biophysical Research Communications 362, 928-934 (2007).
3.Kargl, J.,Brown, A.J.,Andersen, L., et al. A selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell function. Journal of Pharmacology and Experimental Therapeutics 346, 54-66 (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 425.4 |
| 分子式 | C25H19N3O4 |
| CAS号 | 834903-43-4 |
| 稳定性 | ≥ 2 years |
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