ML-289
货号：
15195-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 15195-1mg |
| 描述 | Glutamate, the major excitatory neurotransmitter in the CNS, activates eight known subtypes of metabotropic glutamate receptors (mGluRs). Highly selective modulators designed to act at allosteric sites within the receptor are being developed to preferentially target individual mGluR subtypes in order to determine their distinct pharmacological roles. ML-298 is a negative allosteric modulator of mGlu3 (IC50 = 0.66 μM) that displays 15-fold selectivity over mGlu2 and inactivity against mGlu5.1 |
| 别名 | VU0463597; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sheffler, D.J.,Wenthur, C.J.,Bruner, J.A., et al. Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM. Bioorganic & Medicinal Chemistry Letters 22(12), 3921-3925 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 349.4 |
| 分子式 | C22H23NO3 |
| CAS号 | 1382481-79-9 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
