ML-239
货号：
15188-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 15188-1mg |
| 描述 | ML-239 is an inhibitor of cancer stem cells, displaying greater than 23-fold selective inhibition of a breast cancer stem cell-like cell line (EC50 = 1.18 µM) over an isogenic control cell line (EC50 = 27.6 µM).1,2,3 It is also toxic to the breast carcinoma cell line MDA-MB-231.1 ML-239 alters the expression of genes in the MAPK, NF-κB, and inflammatory cytokine pathways.1,3 It is stable in saline and modestly stable in human plasma.2 |
| 别名 | CID-49843203; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Carmody, L.C.,Germain, A.R.,VerPlank, L., et al. Phenotypic high-throughput screening elucidates target pathway in breast cancer stem cell-like cells. Journal of Biomolecular Screening 17(9), 1204-1210 (2012).
2.Germain, A.R.,Carmody, L.C.,Morgan, B., et al. Identification of a selective small molecule inhibitor of breast cancer stem cells. Bioorganic & Medicinal Chemistry Letters 22(10), 3571-3574 (2012).
3.Carmody, L.,Garmain, A.,Morgan, B., et al. Identification of a selective small-molecule inhibitor of breast cancer stem cells - Probe 1. 1, 1-13 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 346.6 |
| 分子式 | C13H10Cl3N3O2 |
| CAS号 | 1378872-36-6 |
| 稳定性 | ≥ 2 years |
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