| 货号 | 15160-1mg |
| 描述 | PPACK is a synthetic peptide derivative that irreversibly and specifically inhibits thrombin-mediated platelet activation by binding with high affinity to the active site of thrombin (Ki = 0.24 nM).1,2,3 It has been used as an anticoagulant (100 μM) and to study thrombin-mediated fibrin deposition, angiogenesis, and proinflammatory processes.4,5 |
| 别名 | Pebac;D-Phenylalanyl-prolyl-arginyl Chloromethyl Ketone; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kovach, I.M.,Kelley, P.,Eddy, C., et al. Proton bridging in the interactions of thrombin with small inhibitors. Biochemistry 48(30), 7296-7304 (2009). 2.Bode, W.,Turk, D. and Karshikov, A. The refined 1.9-Å x-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships. Protein Science 1(4), 426-471 (1992). 3.Hanson, S.R. and Harker, L.A. Interruption of acute platelet-dependent thrombosis by the synthetic antithrombin D-phenylalanyl-L-prolyl-L-arginyl chloromethyl ketone. Proceedings of the National Academy of Sciences of the United States of America 85(9), 3184-3488 (1988). 4.Lyon, M.E.,Fine, J.S.,Henderson, P.J., et al. D-phenylalanyl-L-prolyl-L-arginine chloromethyl ketone (PPACK): Alternative anticoagulant to heparin salts for blood gas and electrolyte specimens. Clinical Chemistry 41(7), 1038-1041 (1995). 5.Liu, J.F.,Hou, S.M.,Tsai, C.H., et al. Thrombin induces heme oxygenase-1 expression in human synovial fibroblasts through protease-activated receptor signaling pathways. Arthritis Research & Therapy 14(2), R91 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 451 |
| 分子式 | C21H31ClN6O3 |
| CAS号 | 71142-71-7 |
| 稳定性 | ≥ 2 years |
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