| 货号 | 15141-1mg |
| 描述 | Type 4 cyclic nucleotide phosphodiesterase (PDE4) isoforms selectively inactivate the second messenger cAMP by hydrolyzing the phosphodiester bond, producing AMP.1 Roflumilast is a potent, cell-permeable inhibitor of PDE4 (IC50=< 1 nM for both human PDE4B and PDE4D).2 It is selective for PDE4, with IC50 values against other PDE forms being greater than 10 μM.2 Roflumilast demonstrates good bioavailability and has applications in respiratory diseases, including asthma and chronic obstructive pulmonary disease.3,4 |
| 别名 | B 9302-107;BY 217;BYK 20869;Daxas; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.DeNinno, M.P. Future directions in phosphodiesterase drug discovery. Bioorganic & Medicinal Chemistry Letters 22(22), 6794-6800 (2012). 2.Card, G.L.,England, B.P.,Suzuki, Y., et al. Structural basis for the activity of drugs that inhibit phosphodiesterases. Structure 12(12), 2233-2247 (2004). 3.Spina, D. PDE4 inhibitors: Current status. British Journal of Pharmacology 155, 308-315 (2008). 4.Kodimuthali, A.,Jabaris, S.S.L. and Pal, M. Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease. Journal of Medicinal Chemistry 51(18), 5471-5489 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 403.2 |
| 分子式 | C17H14Cl2F2N2O3 |
| CAS号 | 162401-32-3 |
| 稳定性 | ≥ 2 years |
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