| 货号 | 15116-5mg |
| 描述 | Vitexin is an apigenin flavone C-glycoside isolated from Crataegus spp. (hawthorn), Passiflora spp. (passionflower), P. glaucum R. Br. (pearl millet), P. nigra (bamboo leaves), V. agnuscastus L. (chasteberry), and various other tropical plant species.1,2,3 It demonstrates antioxidant activity in a DPPH bleaching assay (IC50 = 24.2 μM) and also inhibits the activity of the carbohydrate-hydrolyzing enzyme α-glucosidase (IC50 = 244 μM).1,3 It has been shown to have broad anti-tumor activity, activating caspases and inducing apoptosis in cancer xenograft models.4 Additionally, vitexin at 10 mg/kg exhibits an analgesic effect in several different models of inflammatory pain by targeting TRPV1 channel activity, by preventing the decrease of reduced glutathione levels, and by modulating the production of cytokines.5 |
| 别名 | Orientoside; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Simirgiotis, M.J.,Schmeda-Hirschmann, G.,Bórquez, J., et al. The Passiflora tripartita (banana passion) fruit: A source of bioactive flavonoid C-glycosides isolated by HSCCC and characterized by HPLC-DAD-ESI/MS/MS. Molecules 18(2), 1672-1692 (2013). 2.Wang, J.,Yue, Y.D.,Jiang, H., et al. Rapid screening for flavone C-glycosides in the leaves of different species of bamboo and simultaneous quantitation of four marker compounds by HPLC-UV/DAD. Int.J.Anal.Chem. 2012, 1-8 (2012). 3.Chen, Y.G.,Ping, L.,Peng, L., et al. α-Glucosidase inhibitory effect and simultaneous quantification of three major flavonoid glycosides in Microctis folium. Molecules 18(4), 4221-4232 (2013). 4.Zhou, Y.,Liu, Y.E.,Cao, J., et al. Vitexins, nature-derived lignan compounds, induce apoptosis and suppress tumor growth. Clinical Cancer Research 15(16), 5161-5169 (2009). 5.Borghi, S.M.,Carvalho, T.T.,Staurengo-Ferrari, L., et al. Vitexin inhibits inflammatory pain in mice by targeting TRPV1, oxidative stress, and cytokines. Journal of Natural Products 76(6), 1141-1149 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 432.4 |
| 分子式 | C21H20O10 |
| CAS号 | 3681-93-4 |
| 稳定性 | ≥ 2 years |
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