| 货号 | 15024-1g |
| 描述 | β-Lactams are a large class of antibiotics that includes penicillins, cephalosporins, carbapenems, and monobactams.1 Resistance against β-lactam antibiotics can result from the production of β-lactamases, which is a common mechanism employed by Gram-negative bacteria.1,2 Sulbactam is a penicillanic acid sulfone that acts as an irreversible inhibitor of β-lactamases.3 It is effective against a wide variety of serine β-lactamases produced by common Gram-negative and Gram-positive aerobes and anaerobes.4,5,6 However, it is not effective against metallo-β-lactamases, cephalosporinases, or oxacillinases.6 |
| 别名 | CP 45,899;Penicillanic Acid Dioxide; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Worthington, R.J. and Melander, C. Overcoming resistance to β-lactam antibiotics. The Journal of Organic Chemistry 78(9), 4207-4213 (2013). 2.Fair, R.J. and Tor, Y. Antibiotics and bacterial resistance in the 21st century. Perspectives in Medicinal Chemistry 6, 25-64 (2014). 3.Bush, K. β-Lactamase inhibitors from laboratory to clinic. Clin.Microbiol.Rev. 1(1), 109-123 (1988). 4.Williams, J.D. β-Lactamase inhibition and in vitro activity of sulbactam and sulbactam/cefoperazone. Clinical Infectious Diseases 24(3), 494-497 (1997). 5.Chaïbi, E.B.,Sirot, D.,Paul, G., et al. Inhibitor-resistant TEM β-lactamases: Phenotypic, genetic and biochemical characteristics. Journal of Antimicrobial Chemotherapy 43(4), 447-458 (1999). 6.Drawz, S.M. and Bonomo, R.A. Three decades of β-lactamase inhibitors. Clin.Microbiol.Rev. 23(1), 160-201 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 233.2 |
| 分子式 | C8H11NO5S |
| CAS号 | 68373-14-8 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |