| 货号 | 14969-1mg |
| 描述 | Histone deacetylases (HDACs) catalyze the hydrolytic removal of acetyl groups from histone lysine residues, which commonly results in chromatin condensation and transcriptional repression.1,2 LMK 235 is an HDAC inhibitor that selectively targets HDACs 4 and 5 (IC50s = 12 and 4 nM, respectively) over other HDACs (IC50s = 56, 320, 850, 880, and 1,280 for HDACs 6, 1, 11, 2, and 8, respectively).3 It displays enhanced cytotoxic effects against human cancer cell lines, compared to SAHA (Item No. 10009929) or trichostatin A (Item No. 89730).3 LMK 235 and derivatives inhibit the growth of the malarial parasite P. falciparum at multiple life cycle stages at nanomolar concentrations.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Strahl, B.D. and Allis, D. The language of covalent histone modifications. Nature 403, 41-45 (2000). 2.Cheung, W.L.,Briggs, D.B. and Allis, C.D. Acetylation and chromosomal functions. Current Opinion in Cell Biology 12, 326-333 (2000). 3.Marek, L.,Hamacher, A.,Hansen, F.K., et al. Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells. Journal of Medicinal Chemistry 56, 427-436 (2016). 4.Hansen, F.K.,Sumanadasa, S.D.M.,Stenzel, K., et al. Discovery of HDAC inhibitors with potent activity against multiple malaria parasite life cycle stages. European Journal of Medicinal Chemistry 82, 204-213 (2014). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 294.4 |
| 分子式 | C15H22N2O4 |
| CAS号 | 1418033-25-6 |
| 稳定性 | ≥ 2 years |
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