Nafamostat (mesylate)
货号：
14837-5mg 基本售价：
406.0 元 规格：
5 mg
产品信息
概述| 货号 | 14837-5mg |
| 描述 | Nafamostat is a serine protease inhibitor that is capable of inhibiting trypsin (a digestive system protease; Ki = 15 nM), tryptase (a mast cell protease; Ki = 95.3 pM), and additional proteases in the coagulation cascade including thrombin (Ki = 0.84 μM).1 In a mouse model of allergic asthma, a dose of 300 mg/kg nafamostat mesylate has been shown to inhibit serine proteolytic activity, to decrease circulating levels of eosinophils and lymphocytes in bronchoalveolar lavage fluid, and to reduce interleukin-13 and eotaxin production associated with antigen-induced airway eosinophilia and goblet cell hyperplasia.2 |
| 别名 | Coahibitor;FUT 175;Nafamastat; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mori, S.,Itoh, Y.,Shinohata, R., et al. Nafamostat mesilate is an extremely potent inhibitor of human tryptase. Journal of Pharmacological Sciences 92(4), 420-423 (2003).
2.Ishizaki, M.,Tanaka, H.,Kajiwara, D., et al. Nafamostat mesilate, a potent serine protease inhibitor, inhibits airway eosinophilic inflammation and airway epithelial remodeling in a murine model of allergic asthma. Journal of Pharmacological Sciences 108(3), 355-363 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 539.6 |
| 分子式 | C19H17N5O2 • 2CH3SO3H |
| CAS号 | 82956-11-4 |
| 稳定性 | ≥ 2 years |
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