| 货号 | 14831-1mg |
| 描述 | Casein kinase 2 (CK2) is a kinase with many targets and diverse roles in cell signaling and disease.1,2 TBCA is a selective, cell-permeable inhibitor of CK2 (IC50 = 0.11 µM, Ki = 77 nM) that has minimal effect on a panel of 28 other kinases.3 It induces cell death in Jurkat adult T cell leukemia cells (DC50 = 7.7 µM), driving caspase-dependent degradation of poly-ADP ribose polymerase while inhibiting CK2 activity.3 TBCA also supports a role for CK2 in platelet function and Akt phosphorylation but not protein splicing.4,5 |
| 别名 | Casein Kinase II Inhibitor III;Tetrabromocinnamic Acid; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.López-Ramos, M.,Prudent, R.,Moucadel, V., et al. New potent dual inhibitors of CK2 and Pim kinases: Discovery and structural insights. The FASEB Journal 24(9), 3171-3185 (2010). 2.Pagano, M.A.,Cesaro, L.,Meggio, F., et al. Protein kinase CK2: A newcomer in the druggable kinome. Biochemical Society Transactions 34(Pt 6), 1303-1306 (2006). 3.Pagano, M.A.,Poletto, G.,Di Maira, G., et al. Tetrabromocinnamic acid (TBCA) and related compounds represent a new class of specific protein kinase CK2 inhibitors. ChemBioChem 8(1), 129-139 (2007). 4.Ryu, S.Y. and Kim, S. Evaluation of CK2 inhibitor (E)-3-(2,3,4,5-tetrabromophenyl)acrylic acid (TBCA) in regulation of platelet function. European Journal of Pharmacology 720(1-3), 391-400 (2013). 5.Kim, H.,Choi, K.,Kang, H., et al. Identification of a novel function of CX-4945 as a splicing regulator. PLoS One 9(4), e94978 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 463.7 |
| 分子式 | C9H4Br4O2 |
| CAS号 | 934358-00-6 |
| 稳定性 | ≥ 2 years |
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