| 货号 | 14612-5g |
| 描述 | 7-dehydro Cholesterol (7-DHC) is an immediate precursor of cholesterol. It is reduced to cholesterol by the enzyme 3β-hydroxysterol-Δ7-reductase (DHCR7) in the last step of cholesterol biosynthesis from squalene. Mutations in the gene encoding DHCR7 lead to increased levels of 7-DHC and the neurodevelopmental syndrome Smith-Lemli-Opitz syndrome (SLOS).1 7-DHC is elevated in rats treated with the DHCR7 inhibitor AY9944, an animal model of SLOS.2 7-DHC is subject to free radical oxidation (autoxidation), giving rise to several oxysterols which contribute to pathogenesis.3 Serum levels of 7-DHC, largely derived from the liver, are approximately 0.3 μM in healthy individuals.4 In the skin, photolysis of 7-DHC by ultraviolet light produces vitamin D3 (Item No. 11792).5,6 |
| 别名 | Δ7-Cholesterol;7-DHC;NSC 18159;Provitamin D3; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Liu, W.,Xu, L.,Lamberson, C.R., et al. Assays of plasma dehydrocholesteryl esters and oxysterols from Smith-Lemli-Opitz syndrome patients. Journal of Lipid Research 54, 244-253 (2013). 2.Xu, L.,Liu, W.,Sheflin, L.G., et al. Novel oxysterols observed in tissues and fluids of AY9944-treated rats: A model for Smith-Lemli-Opitz syndrome. Journal of Lipid Research 52, 1810-1820 (2011). 3.Xu, L.,Korade, Z.,Rosado, D.A., Jr., et al. Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells. Journal of Lipid Research 54, 1135-1143 (2013). 4.Glossmann, H.H. Origin of 7-dehydrocholesterol (provitamin D) in the skin. Journal of Investigative Dermatology 130(8), 2139-2141 (2010). 5.Lehmann, B.,Genehr, T.,Knuschke, P., et al. UVB-induced conversion of 7-dehydrocholesterol to 1α,25-dihydroxyvitamin D3 in an in vitro human skin equivalent model. Journal of Investigative Dermatology 117(5), 1179-1185 (2001). 6.Chen, T.C.,Chimeh, F.,Lu, Z., et al. Factors that influence the cutaneous synthesis and dietary sources of vitamin D. Archives of Biochemistry and Biophysics 460(2), 213-217 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 384.6 |
| 分子式 | C27H44O |
| CAS号 | 434-16-2 |
| 稳定性 | ≥ 2 years |
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