SD 169
货号：
14156-5mg 基本售价：
406.0 元 规格：
5 mg
产品信息
概述| 货号 | 14156-5mg |
| 描述 | SD 169 is a selective ATP competitive inhibitor of the MAP kinases p38α (IC50 = 3.2 nM) and p38β (IC50 = 122 nM).1 It has no inhibitory effect against a panel of other kinases, including p38γ MAP kinase, ERK2, JNK-1, and MAPKAPK-2, when tested in vitro at 50 μM.1 SD 169 is orally active, significantly reducing p38 MAP kinase expression in T cells of nonobese diabetic mice when delivered in chow at 600 mg/kg.1 In this model, SD 169 also reduced the incidence of diabetes, lowered blood glucose, and improved glucose homeostasis.1 SD 169 also enhances axonal regeneration after sciatic nerve crush injury in rats, when given by gavage (30 mg/kg) before and after nerve damage.2 |
| 别名 | 5-Carbamoylindole; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Medicherla, S.,Protter, A.A.,Ma, J.Y., et al. Preventive and therapeutic potential of p38α-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes. Journal of Pharmacology and Experimental Therapeutics 318(1), 99-107 (2006).
2.Myers, R.R.,Sekiguchi, Y.,Kikuchi, S., et al. Inhibition of p38 MAP kinase activity enhances axonal regeneration. Experimental Neurology 184(2), 606-614 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 160.2 |
| 分子式 | C9H8N2O |
| CAS号 | 1670-87-7 |
| 稳定性 | ≥ 2 years |
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